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Toward more selective antiarthritic therapy T. Y. Shen pp 1 - 5; DOI: 10.1021/jm00133a001 |
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Potential organ- or tumor-imaging agents. 21. Acyl-labeled esters of cholesterol R. E. Counsell, R. H. Seevers, N. Korn, and S. W. Schwendner pp 5 - 6; DOI: 10.1021/jm00133a002 |
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Importance of the aromatic ring in adrenergic amines. 5. Nonaromatic analogs of phenylethanolamine as inhibitors of phenylethanolamine N-methyltransferase: role of hydrophobic and steric interactions William C. Vincek, Constance S. Aldrich, Ronald T. Borchardt, and Gary L. Grunewald pp 7 - 12; DOI: 10.1021/jm00133a003 |
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Importance of the aromatic ring in adrenergic amines. 6. Nonaromatic analogs of phenylethanolamine as inhibitors of phenylethanolamine N-methyltransferase: role of .pi.-electronic and steric interactions Dwight P. Davis, Ronald T. Borchardt, and Gary L. Grunewald pp 12 - 16; DOI: 10.1021/jm00133a004 |
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.alpha.-Ethynyl and .alpha.-vinyl analogs of ornithine as enzyme-activated inhibitors of mammalian ornithine decarboxylase Charles Danzin, Patrick Casara, Nicole Claverie, and Brian W. Metcalf pp 16 - 20; DOI: 10.1021/jm00133a005 |
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Novel peptidoaminobenzophenones, terminal N-substituted peptidoaminobenzophenones, and N-(acylglycyl)aminobenzophenones as open-ring derivatives of benzodiazepines Kentaro Hirai, Teruyuki Ishiba, Hirohiko Sugimoto, Toshio Fujishita, Yuji Tsukinoki, and Katsumi Hirose pp 20 - 27; DOI: 10.1021/jm00133a006 |
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Regiospecific attack of nitrogen and sulfur nucleophiles on quinones derived from poison oak/ivy catechols (urushiols) and analogs as models for urushiol-protein conjugate formation Daniel J. Liberato, Vera S. Byers, Reg G. Dennick, and Neal Castagnoli pp 28 - 33; DOI: 10.1021/jm00133a007 |
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Permethyl analog of the pyrrolic antibiotic distamycin A Paul L. Gendler and Henry Rapoport pp 33 - 38; DOI: 10.1021/jm00133a008 |
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Synthesis and antiinflammatory activity of metabolites of piroxicam Joseph G. Lombardino pp 39 - 42; DOI: 10.1021/jm00133a009 |
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Nonsteroidal antiinflammatroy agents. 2. Synthesis of 4',5-disubstituted 3-diphenylylacetic acids and their derivatives with antiinflammatory and analgesic activities Yasumitsu Tamura, Yoshihiko Yoshimoto, Katsutoshi Kunimoto, Shinichi Tada, Shingo Matsumura, Masao Murayama, Yoshihisa Shibata, and Hiroshi Enomoto pp 43 - 47; DOI: 10.1021/jm00133a010 |
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New antiarrhythmic agents. 4. 1'-(aminoalkyl)-1,2,3,4-tetrahydronaphthalene-1-spiro-3'-pyrrolidine-2',5'-dione derivatives Paul A. Tenthorey, Robert A. Ronfeld, Hal S. Feldman, Rune V. Sandberg, Paul D. McMaster, and Emil R. Smith pp 47 - 53; DOI: 10.1021/jm00133a011 |
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New antiarrhythmic agents. 5. .alpha.-Aminoaceto-2,6-xylidides with functionalized amide alkyl substituents Paul D. McMaster, Eugene W. Byrnes, Alan J. Block, and Paul A. Tenthorey pp 53 - 58; DOI: 10.1021/jm00133a012 |
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Synthesis and antihypertensive activity of new 6-heteroaryl-3-hydrazinopyridazine derivatives Gerd Steiner, Josef Gries, and Dieter Lenke pp 59 - 63; DOI: 10.1021/jm00133a013 |
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Tetrahydro-2-benzoxepins: a novel family of hypotensives Ruth E. TenBrink, John M. McCall, Donald T. Pals, Robert B. McCall, John Orley, Steve J. Humphrey, and Michael G. Wendling pp 64 - 67; DOI: 10.1021/jm00133a014 |
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1-(Naphthylalkyl)-1H-imidazole derivatives, a new class of anticonvulsant agents Keith A. M. Walker, Marshall B. Wallach, and Donald R. Hirschfeld pp 67 - 74; DOI: 10.1021/jm00133a015 |
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Novel tetracyclic spiropiperidines. 1. 3-Aryl-1,3-dihydrospiro[benzo[c]thiophene-1,4'-piperidines] as potential antidepressants Helen H. Ong, James A. Profitt, V. Brian Anderson, Hansjoerg Kruse, Jeffrey C. Wilker, and Harry M. Geyer pp 74 - 79; DOI: 10.1021/jm00133a016 |
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Synthesis and stereochemistry of 7-phenyl-2-propionanilidobenzo[a]quinolizidine derivatives. Structural probes of fentanyl analgesics Bruce E. Maryanoff, David F. McComsey, Russell J. Taylor, and Joseph F. Gardocki pp 79 - 88; DOI: 10.1021/jm00133a017 |
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1-Oxacephalosporins: enhancement of .beta.-lactam reactivity and antibacterial activity Kazuhisa Murakami, Mamoru Takasuka, Kiyoshi Motokawa, and Tadashi Yoshida pp 88 - 93; DOI: 10.1021/jm00133a018 |
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Piperazinylquinoxalines with central serotoninmimetic activity William C. Lumma, Richard D. Hartman, Walfred S. Saari, Edward L. Engelhardt, Victor J. Lotti, and Clement A. Stone pp 93 - 101; DOI: 10.1021/jm00133a019 |
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Fluorinated retinoic acids and their analogs. 2. Synthesis and biological activity of aromatic 4-fluoro analogs Ka-Kong Chan, Anthony C. Specian, and Beverly A. Pawson pp 101 - 104; DOI: 10.1021/jm00133a020 |
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Synthesis and angiotensin-converting enzyme inhibitory activity of 3-(mercaptomethyl)-2-oxo-1-pyrrolidineacetic acids and 3-(mercaptomethyl)-2-oxo-1-piperidineacetic acids Sylvester Klutchko, Milton L. Hoefle, Ronald D. Smith, Arnold D. Essenburg, Robert B. Parker, Vicki L. Nemeth, Michael Ryan, Deborah H. Dugan, and Harvey R. Kaplan pp 104 - 109; DOI: 10.1021/jm00133a021 |
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Synthesis and antiviral activity of 1-(2-deoxy-.beta.-D-ribofuranosyl)-5-(methylmercapto)-2-pyrimidinone Alan C. Schroeder, Thomas J. Bardos, and Yung-Chi Cheng pp 109 - 112; DOI: 10.1021/jm00133a022 |
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Synthesis of 2'-deoxy-L-fucopyranosylcarminomycinone and -.epsilon.-pyrromycinone as well as 2'-deoxy-D-erythro-pentopyranosyldaunomycinone, -carminomycinone, and -.epsilon.-pyrromycinone Hassan S. El Khadem and David L. Swartz pp 112 - 115; DOI: 10.1021/jm00133a023 |
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2-(Aminomethyl)phenols, a new class of saluretic agents. 2. Synthesis and pharmacological properties of the 5-aza isostere of 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol G. E. Stokker, R. L. Smith, E. J. Cragoe, C. T. Ludden, H. F. Russo, C. S. Sweet, and L. S. Watson pp 115 - 117; DOI: 10.1021/jm00133a024 |
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Synthesis and study of the potential antiallergic activity of some pyrazole derivatives Maria T. Di Parsia, Cecilia Suarez, Maria J. Vitolo, Victor E. Marquez, Bernardo Beyer, Cecilia Urbina, and Ines Hurtado pp 117 - 119; DOI: 10.1021/jm00133a025 |
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Book Reviews pp 120 - 120; DOI: 10.1021/jm00133a600 |
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The leukotrienes: a major step in the understanding of immediate hypersensitivity reactions Pierre Borgeat and Pierre Sirois pp 121 - 126; DOI: 10.1021/jm00134a001 |
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Synthesis and antimalarial effects of N2-aryl-N4-[(dialkylamino)alkyl]- and N4-aryl-N2-[(dialkylamino)alkyl]-2,4-quinazolinediamines Edward F. Elslager, Carolyn Hess, Judith Johnson, Daniel Ortwine, Vera Chu, and Leslie M. Werbel pp 127 - 140; DOI: 10.1021/jm00134a002 |
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Folate antagonists. 18. Synthesis and antimalarial effects of N6-(arylmethyl)-N6-methyl-2,4,6-pteridinetriamines and related N6,N6-disubstituted 2,4,6-pteridinetriamines Edward F. Elslager, Judith L. Johnson, and Leslie M. Werbel pp 140 - 145; DOI: 10.1021/jm00134a003 |
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Synthesis and antidepressant activity of substituted (.omega.-aminoalkoxy)benzene derivatives Ryoji Kikumoto, Akihiro Tobe, and Shinji Tonomura pp 145 - 148; DOI: 10.1021/jm00134a004 |
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5,7-Dihydroxy-2-aminotetralin derivatives: synthesis and assessment of dopaminergic and adrenergic actions Joseph G. Cannon, Abram N. Brubaker, John Paul Long, Jan R. Flynn, Turkiz Verimer, Peerarat Harnirattisai, Brenda Costall, Robert J. Naylor, and V. Nohria pp 149 - 153; DOI: 10.1021/jm00134a005 |
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Thiophene systems. 5. Thieno[3,4-b][1,5]benzoxazepines, thieno[3,4-b][1,5]benzothiazepines, and thieno[3,4-b][1,4]benzodiazepines as potential central nervous system agents Jeffery B. Press, Corris M. Hofmann, Nancy H. Eudy, Ivana P. Day, Eugene N. Greenblatt, and Sidney R. Safir pp 154 - 159; DOI: 10.1021/jm00134a006 |
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Synthesis and antiarrhythmic activity of new benzofuran derivatives Guy Bourgery, Philippe Dostert, Alain Lacour, Michel Langlois, Bernard Pourrias, and Jacky Tisne-Versailles pp 159 - 167; DOI: 10.1021/jm00134a007 |
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Synthesis of seleno- and thioguanine-platinum(II) complexes and their antitumor activity in mice Mitsuaki Maeda, Noriko Abiko, and Takuma Sasaki pp 167 - 169; DOI: 10.1021/jm00134a008 |
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Potential antitumor agents. 34. Quantitative relationships between DNA binding and molecular structure for 9-anilinoacridines substituted in the anilino ring Bruce C. Baguley, William A. Denny, Graham J. Atwell, and Bruce F. Cain pp 170 - 177; DOI: 10.1021/jm00134a009 |
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New monofunctional reagents for DNA as possible agents for the photochemotherapy of psoriasis: derivatives of 4,5'-dimethylangelicin Francesco Dall'Acqua, Daniela Vedaldi, Sergio Caffieri, Adriano Guiotto, Paolo Rodighiero, Francarosa Baccichetti, Francesco Carlassare, and Franco Bordin pp 178 - 184; DOI: 10.1021/jm00134a010 |
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Potential inhibitors of nucleotide biosynthesis. 1. Nitrosoureidonucleosides. 2 John A. Montgomery, H. Jeanette Thomas, R. Wallace Brockman, and Glynn P. Wheeler pp 184 - 189; DOI: 10.1021/jm00134a011 |
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Inactivation of liver alcohol dehydrogenases and inhibition of ethanol metabolism by ambivalent active-site-directed reagents Wen-Sherng Chen, David P. Bohlken, and Bryce V. Plapp pp 190 - 193; DOI: 10.1021/jm00134a012 |
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Synthesis and structure-activity relationship of spiro[isochromanpiperidine] analogs for inhibition of histamine release. 1 Masatoshi Yamato, Kuniko Hashigaki, Masao Ikeda, Hidetoshi Ohtake, and Kenji Tasaka pp 194 - 198; DOI: 10.1021/jm00134a013 |
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Quantitative structure-activity relationships by distance geometry: thyroxine binding site Gordon M. Crippen pp 198 - 203; DOI: 10.1021/jm00134a014 |
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Synthetic enterobactin analogs. Carboxamido-2,3-dihydroxyterephthalate conjugates of spermine and spermidine Frederick L. Weitl, Kenneth N. Raymond, and Patricia W. Durbin pp 203 - 206; DOI: 10.1021/jm00134a015 |
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Comparison of solution conformational preferences for the hallucinogens bufotenin and psilocin using 360-MHz proton NMR spectroscopy Gerald P. Migliaccio, Tiee-Leou N. Shieh, Stephen R. Byrn, Bruce A. Hathaway, and David E. Nichols pp 206 - 209; DOI: 10.1021/jm00134a016 |
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Studies on position 1 of angiotensin II: effects on affinity and duration of action from alkyl amide substitution Paul Cordopatis, Dimitrios Theodoropoulos, Gaetan Guillemette, and Emanuel Escher pp 209 - 211; DOI: 10.1021/jm00134a017 |
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Some 14.beta.-substituted analogs of N-(cyclopropylmethyl)normorphine Peter Osei-Gyimah, Sydney Archer, Maureen G. C. Gillan, and Hans W. Kosterlitz pp 212 - 214; DOI: 10.1021/jm00134a018 |
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Synthesis and antimalarial activity of 8-[(1-alkyl-4-aminobutyl)amino]-6-methoxy-4-methylquinolines Shou-Jen Yan, Ping-Lu Chien, and C. C. Cheng pp 215 - 217; DOI: 10.1021/jm00134a019 |
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Structure-activity studies on narcotic antagonists. 2. N-substituted ethyl3-(m- or p-hydroxyphenyl)nipecotates Ronald L. Jacoby, Dick Boon, Leonard E. Darling, and Robert E. Willette pp 218 - 221; DOI: 10.1021/jm00134a020 |
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Some analogs of luteinizing hormone-releasing hormone with substituents in position 10 Satoe H. Nakagawa, Dai Chang Yang, and George Flouret pp 221 - 223; DOI: 10.1021/jm00134a021 |
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Book Reviews pp 224 - 228; DOI: 10.1021/jm00134a600 |
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A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry Yvonne C. Martin pp 229 - 237; DOI: 10.1021/jm00135a001 |
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Proposed dopaminergic pharmacophore of lergotrile, pergolide, and related ergot alkaloid derivatives Joseph G. Cannon, Basil J. Demopoulos, John Paul Long, Jan R. Flynn, and Fouad M. Sharabi pp 238 - 240; DOI: 10.1021/jm00135a002 |
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Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines Kohtaro Yuta and Peter C. Jurs pp 241 - 251; DOI: 10.1021/jm00135a003 |
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Quantitative structure-activity relationships of colchicines against P388 leukemia in mice Frank R. Quinn and John A. Beisler pp 251 - 256; DOI: 10.1021/jm00135a004 |
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Biological effects of modified colchicines. Improved preparation of 2-demethylcolchicine, 3-demethylcolchicine, and (+)-colchicine and reassignment of the position of the double bond in dehydro-7-deacetamidocolchicines Manfred Roesner, Hans-Georg Capraro, Arthur E. Jacobson, Louise Atwell, Arnold Brossi, Maria A. Iorio, Thomas H. Williams, Robert H. Sik, and Colin F. Chignell pp 257 - 261; DOI: 10.1021/jm00135a005 |
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Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity Stefan H. Unger and Grace H. Chiang pp 262 - 270; DOI: 10.1021/jm00135a006 |
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Mechanism of action of (2-haloethyl)nitrosoureas on DNA. Isolation and reactions of postulated 2-(alkylimino)-3-nitrosooxazolidine intermediates in the decomposition of 1,3-bis(2-chloroethyl)-, 1-(2-chloroethyl)-3-cyclohexyl-, and 1-(2-chloroethyl)-3-(4'-trans-methylcyclohexyl)-1-nitrosourea J. William Lown and Shive M. S. Chauhan pp 270 - 279; DOI: 10.1021/jm00135a007 |
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Synthesis and DNA binding of [3-[2'-(2-acetamidoethyl)-2,4'-bithiazole-4-carboxamido]propyl]dimethylsulfonium chloride, a fragment of bleomycin A2 Ted T. Sakai, James M. Riordan, Thomas E. Booth, and Jerry D. Glickson pp 279 - 285; DOI: 10.1021/jm00135a008 |
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Esters of isoguvacine as potential prodrugs Erik Falch, Povl Krogsgaard-Larsen, and Anne Vibeke Christensen pp 285 - 289; DOI: 10.1021/jm00135a009 |
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Bioactivation of the antitumor drugs 9-hydroxyellipticine and derivatives by a peroxidase-hydrogen peroxide system Christian Auclair and Claude Paoletti pp 289 - 295; DOI: 10.1021/jm00135a010 |
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In vitro activity of 2-alkyl-3-hydroxy-1,4-naphthoquinones against Theileria parva Peter Boehm, Kelvin Cooper, Alan T. Hudson, Jane P. Elphick, and Nicholas McHardy pp 295 - 299; DOI: 10.1021/jm00135a011 |
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Studies on chiral interactions of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane and the corresponding n-hydroxy metabolites with cytochrome P-450 N. Peter McGraw and N. Castagnoli pp 299 - 304; DOI: 10.1021/jm00135a012 |
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Puromycin analogs. Effect of aryl-substituted puromycin analogs on the ribosomal peptidyltransferase reaction Heejoo Lee, Kei-Lai Fong, and Robert Vince pp 304 - 308; DOI: 10.1021/jm00135a013 |
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Ring-hydroxylated propranolol: synthesis and .beta.-receptor antagonist and vasodilating activities of the seven isomers J. E. Oatis, M. P. Russell, D. R. Knapp, and T. Walle pp 309 - 314; DOI: 10.1021/jm00135a014 |
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.beta.-Adrenoceptor stimulant properties of amidoalkylamino-substituted 1-aryl-2-ethanols and 1-(aryloxy)-2-propanols Jeffrey J. Barlow, Brian G. Main, and H. Michael Snow pp 315 - 322; DOI: 10.1021/jm00135a015 |
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Fibrin polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization Kun-hwa Hsieh, M. Susan Mudd, and George D. Wilner pp 322 - 327; DOI: 10.1021/jm00135a016 |
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Salicylamide derivatives related to medroxalol with .alpha.- and .beta.-adrenergic antagonist and antihypertensive activity J. Martin Grisar, George P. Claxton, Thomas M. Bare, Richard C. Dage, Hsien C. Cheng, and James K. Woodward pp 327 - 336; DOI: 10.1021/jm00135a017 |
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Imine analogs of tricyclic antidepressants Engelbert Ciganek, Roy T. Uyeda, Marvin Cohen, and Dewey H. Smith pp 336 - 341; DOI: 10.1021/jm00135a018 |
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4-Aryl-4-aminocyclohexanones and their derivatives, a novel class of analgesics. 3. m-Hydroxyphenyl derivatives Daniel Lednicer, Philip F. Von Voigtlander, and D. Edward Emmert pp 341 - 346; DOI: 10.1021/jm00135a019 |
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Cognition-activating properties of 3-(aryloxy)pyridines Donald E. Butler, B. P. H. Poschel, and John G. Marriott pp 346 - 350; DOI: 10.1021/jm00135a020 |
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Nucleosides containing chemically reactive groups Robert D. Elliott, R. Wallace Brockman, and John A. Montgomery pp 350 - 352; DOI: 10.1021/jm00135a021 |
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Book Reviews pp 353 - 354; DOI: 10.1021/jm00135a600 |
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Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension Miguel A. Ondetti and David W. Cushman pp 355 - 361; DOI: 10.1021/jm00136a001 |
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Photochemical inactivation of the angiotensin receptor of rabbit aorta by N.alpha.-(2-Nitro-5-azidobenzoyl)-[1-aspartic acid,5-isoleucine]angiotensin II Richard E. Galardy and Kathleen A. LaVorgna pp 362 - 366; DOI: 10.1021/jm00136a002 |
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Potential thyroliberin affinity labels. 1. Chloroacetyl-substituted phenylalanylpyrrolidines Richard J. Goebel, Bruce L. Currie, and Cyril Y. Bowers pp 366 - 370; DOI: 10.1021/jm00136a003 |
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Synthesis of peptides by the solid-phase method. 6. Neurotensin, fragments, and analogs S. St-Pierre, J. M. Lalonde, M. Gendreau, R. Quirion, D. Regoli, and F. Rioux pp 370 - 376; DOI: 10.1021/jm00136a004 |
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Cyclic guanidines. 14. Imidazo[1,2-a]thienopyrimidin-2-one derivatives as blood platelet aggregation inhibitors Fumiyoshi Ishikawa, Akira Kosasayama, Hitoshi Yamaguchi, Yoshifumi Watanabe, Junji Saegusa, Seiichi Shibamura, Kyoko Sakuma, Shinichiro Ashida, and Yasushi Abiko pp 376 - 382; DOI: 10.1021/jm00136a005 |
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Antihypertensive activity of 6-arylpyrido[2,3-d]pyrimidin-7-amine derivatives Lawrence R. Bennett, C. John Blankley, Robert W. Fleming, Ronald D. Smith, and Deirdre K. Tessman pp 382 - 389; DOI: 10.1021/jm00136a006 |
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Synthesis and antiviral activity of 5-[(cyanomethylene)oxy]-2'-deoxyuridine Guang-Fu Huang, Masashi Okada, Erik De Clercq, and Paul F. Torrence pp 390 - 393; DOI: 10.1021/jm00136a007 |
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Synthesis and biological evaluation of certain 2'-deoxy-.beta.-D-ribo-and 2.beta.-D-arabinofuranosyl nucleosides of purine-6-carboxamide and 4,8-diaminopyrimido[5,4-d]pyrimidine Prem C. Srivastava, Ganapathi R. Revankar, Roland K. Robins, and Robert J. Rousseau pp 393 - 398; DOI: 10.1021/jm00136a008 |
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Promotion of carbohydrate oxidation in the heart by some phenylglyoxylic acids Ian T. Barnish, Peter E. Cross, John C. Danilewicz, Roger P. Dickinson, and David A. Stopher pp 399 - 404; DOI: 10.1021/jm00136a009 |
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4-Amino-4-arylcyclohexanones and their derivatives: a novel class of analgesics. 2. Modification of the carbonyl function Daniel Lednicer, Philip F. VonVoigtlander, and D. Edward Emmert pp 404 - 408; DOI: 10.1021/jm00136a010 |
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Dihydrochalcone sweeteners. A study of the atypical temporal phenomena Grant E. DuBois, Guy A. Crosby, and Rebecca A. Stephenson pp 408 - 428; DOI: 10.1021/jm00136a011 |
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Monophenolic 2-(dipropylamino)indans and related compounds: central dopamine-receptor stimulating activity Uli Hacksell, Lars Erik Arvidsson, Uno Svensson, J. Lars G. Nilsson, Haakan Wikstroem, Per Lindberg, Domingo Sanchez, Stephan Hjorth, Arvid Carlsson, and Lennart Paalzow pp 429 - 434; DOI: 10.1021/jm00136a012 |
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Chemically reactive estrogens: synthesis and estrogen receptor interactions of hexestrol ether derivatives and 4-substituted deoxyhexestrol derivatives bearing alkylating functions John A. Katzenellenbogen, Robert J. McGorrin, Tochiro Tatee, Robert J. Kempton, Kathryn E. Carlson, and David H. Kinder pp 435 - 450; DOI: 10.1021/jm00136a013 |
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Adrenoceptor blocking agents. Compounds related to metoprolol Kurt Loevgren, Anders Hedberg, and J. Lars G. Nilsson pp 451 - 454; DOI: 10.1021/jm00136a014 |
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Structure-activity relationships in dihydropteroate synthase inhibition by sulfanilamides. Comparison with the antibacterial activity Pier G. De Benedetti, Augusto Rastelli, Chiara Frassineti, and Carlo Cennamo pp 454 - 457; DOI: 10.1021/jm00136a015 |
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Synthesis and pharmacological properties of 1,2,3,4,5,6-hexahydro-1,6-methano-2-benzazocines Paul H. Mazzocchi and Barbara C. Stahly pp 457 - 462; DOI: 10.1021/jm00136a016 |
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Some reactions of 1,4-dihydropyridines with organic azides. Synthesis of 2,7-diazabicyclo[4.1.0]hept-3-enes with analgesic and antiprotozoal activity Brent K. Warren and Edward E. Knaus pp 462 - 464; DOI: 10.1021/jm00136a017 |
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Potential anticonvulsants. 1. 5-Benzylhydantoins Nariman B. Mehta, Cheryl A. Risinger Diuguid, and Francis E. Soroko pp 465 - 468; DOI: 10.1021/jm00136a018 |
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Synthesis and antitumor activity of simple vinyl and .alpha.-methylene-.gamma.-butyrolactone sulfonate esters and silyl enol ethers Peter J. Stang and Warren L. Treptow pp 468 - 472; DOI: 10.1021/jm00136a019 |
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Pyrimidine acyclic nucleosides. 5-Substituted 1-[(2-aminoethoxy)methyl]uracils as candidate antivirals James L. Kelley, Mark P. Krochmal, and Howard J. Schaeffer pp 472 - 474; DOI: 10.1021/jm00136a020 |
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Sulfonate analogs of adenosine nucleotides as inhibitors of nucleotide-binding enzymes Paul H. C. Mundill, Richard W. Fries, Christoph Woenckhaus, and Bryce V. Plapp pp 474 - 477; DOI: 10.1021/jm00136a021 |
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Book Reviews pp 477 - 478; DOI: 10.1021/jm00136a600 |
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A novel connector linkage applicable in prodrug design Philip L. Carl, Prasun K. Chakravarty, and John A. Katzenellenbogen pp 479 - 480; DOI: 10.1021/jm00137a001 |
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1-Aryl-3-azabicyclo[3.1.0]hexanes, a new series of nonnarcotic analgesic agents Joseph W. Epstein, Herbert J. Brabander, William J. Fanshawe, Corris M. Hofmann, Thomas C. McKenzie, Sidney R. Safir, Arnold C. Osterberg, D. B. Cosulich, and F. M. Lovell pp 481 - 490; DOI: 10.1021/jm00137a002 |
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A potent, new, sedative-hypnotic agent: 5,7-dihydro-5,5,7,7-tetramethyl-3-(3-nitrophenyl)furo[3,4-e]-as-triazine 4-oxide G. B. Bennett, R. G. Babington, M. A. Deacon, P. L. Eden, S. P. Kerestan, G. H. Leslie, E. A. Ryan, R. B. Mason, and H. E. Minor pp 490 - 496; DOI: 10.1021/jm00137a003 |
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New analgesic drugs derived from phencyclidine Yossef Itzhak, Asher Kalir, Ben Avi Weissman, and Sasson Cohen pp 496 - 499; DOI: 10.1021/jm00137a004 |
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Oxazepam esters. 3. Intrinsic activity, selectivity, and prodrug effect Gabor Maksay, Eva Palosi, Zsuzsanna Tegyey, and Laszlo Otvos pp 499 - 502; DOI: 10.1021/jm00137a005 |
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Characterization of .alpha.-adrenoceptor populations. Quantitative relationships between cardiovascular effects initiated at central and peripheral .alpha.-adrenoceptors Pieter B. M. W. M. Timmermans, Adriaan De Jonge, Jacques C. A. Van Meel, Frieda P. Slothorst-Grisdijk, Egbert Lam, and Pieter A. Van Zwieten pp 502 - 507; DOI: 10.1021/jm00137a006 |
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Relation of conformation to antitumor activity of platinum(II) complexes of 1,2-cyclohexanediamine and 2-(aminomethyl)cyclohexylamine isomers against leukemia P388 Masahide Noji, Koji Okamoto, Yoshinori Kidani, and Tazuko Tashiro pp 508 - 515; DOI: 10.1021/jm00137a007 |
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Showdomycin analogs: synthesis and antitumor evaluation Naganori Numao, Hiromichi Hemmi, Saulius A. Naujokaitis, Marco Rabinovitz, and John A. Beisler pp 515 - 520; DOI: 10.1021/jm00137a008 |
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Potential antitumor agents. 35. Quantitative relationships between antitumor (L1210) potency and DNA binding for 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) analogs B. C. Baguley, W. A. Denny, G. J. Atwell, and B. F. Cain pp 520 - 525; DOI: 10.1021/jm00137a009 |
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Structure-activity relationship in cinnamamides. 3. Synthesis and anticonvulsant activity evaluation of some derivatives of (E)- and (Z)-m-(trifluoromethyl)cinnamamide A. Balsamo, P. Crotti, A. Lapucci, B. Macchia, F. Macchia, A. Cuttica, and N. Passerini pp 525 - 532; DOI: 10.1021/jm00137a010 |
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Structure-activity relationships in a broad-spectrum anthelmintic series. Acid chloride phenylhydrazones. I. Aryl substitutions and chloride variations Douglas L. Rector, S. D. Folz, R. D. Conklin, L. H. Nowakowski, and Girts Kaugars pp 532 - 538; DOI: 10.1021/jm00137a011 |
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Quantitative structure-selectivity relationships. Comparison of the inhibition of Escherichia coli and bovine liver dihydrofolate reductase by 5-(substituted-benzyl)-2,4-diaminopyrimidines Ren-Li Li, Stephen W. Dietrich, and Corwin Hansch pp 538 - 544; DOI: 10.1021/jm00137a012 |
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Inhibition of bovine and rat liver dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(4-substituted-phenyl)-s-triazines Corwin Hansch, Stephen W. Dietrich, and James Y. Fukunaga pp 544 - 549; DOI: 10.1021/jm00137a013 |
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Inhibitors of polyamine biosynthesis. 9. Effects of S-adenosyl-L-methionine analogs on mammalian aminopropyltransferases in vitro and polyamine biosynthesis in transformed lymphocytes Marvin C. Pankaskie, Mahmoud M. Abdel-Monem, Aarne Raina, Tinchung Wang, and John E. Foker pp 549 - 553; DOI: 10.1021/jm00137a014 |
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Potential inhibitors of L-asparagine biosynthesis. 5. Electrophilic amide analogs of (S)-2,3-diaminopropionic acid Michael Mokotoff and Lawrence W. Logue pp 554 - 559; DOI: 10.1021/jm00137a015 |
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Methotrexate analogs. 13. Chemical and pharmacological studies on amide, hydrazide, and hydroxamic acid derivatives of the glutamate side chain Andre Rosowsky, Cheng-Sein Yu, Jack Uren, Herbert Lazarus, and Michael Wick pp 559 - 567; DOI: 10.1021/jm00137a016 |
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Analogs of the cytostatic cyclic tetrapeptide chlamydocin. Synthesis of N.beta.-(N-maleoylglycyl) and N.beta.-(tert-butyloxycarbonyl) derivatives of cyclo(Gly-L-Phe-D-Pro-L-Dap) Daniel H. Rich, Ronald D. Jasensky, Gerald C. Mueller, and Kristin E. Anderson pp 567 - 572; DOI: 10.1021/jm00137a017 |
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Structure-sweetness relationship of L-aspartyl dipeptide analogs. A receptor site topology Hajime Iwamura pp 572 - 583; DOI: 10.1021/jm00137a018 |
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Aromatic retinoic acid analogs. Synthesis and pharmacological activity Marcia I. Dawson, Peter D. Hobbs, Rebecca L. Chan, Wan-Ru Chao, and Victor A. Fung pp 583 - 592; DOI: 10.1021/jm00137a019 |
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Synthesis and anxiolytic activity of 6-(substituted-phenyl)-1,2,4-triazolo[4,3-b]pyridazines J. D. Albright, D. B. Moran, W. B. Wright, J. B. Collins, B. Beer, A. S. Lippa, and E. N. Greenblatt pp 592 - 600; DOI: 10.1021/jm00137a020 |
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Potential radiosensitizing agents. 2. Synthesis and biological activity of derivatives of dinitroimidazole with oxiranes Raj K. Sehgal, Matthew W. Webb, and Krishna C. Agrawal pp 601 - 604; DOI: 10.1021/jm00137a021 |
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Effect of structural change on acute toxicity and antiinflammatory activity in a series of imidazothiazoles and thiazolobenzimidazoles Larry J. Powers, S. W. Fogt, Z. S. Ariyan, D. J. Rippin, R. D. Heilman, and Richard J. Matthews pp 604 - 609; DOI: 10.1021/jm00137a022 |
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Synthesis and antischistosomal activity of certain pyrazolo[1,5-a]pyrimidines Keitaro Senga, Thomas Novinson, Henry R. Wilson, and Roland K. Robins pp 610 - 613; DOI: 10.1021/jm00137a023 |
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Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide Wendel L. Nelson, Cherilyn K. Sneed, Kathleen M. Giacomini, John C. Giacomini, John Stauss, Terrence F. Blaschke, and Brian M. Cox pp 614 - 617; DOI: 10.1021/jm00137a024 |
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Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 6. Synthesis, carbon-13 NMR, and biological evaluation of cis- and trans-4-amino-3'-arylspiro[cyclohexane-1,1'(3'H)-isobenzofuran] derivatives Lawrence L. Martin, Manfred Worm, Marc N. Agnew, Hansjoerg Kruse, Jeffrey C. Wilker, and Harry M. Geyer pp 617 - 621; DOI: 10.1021/jm00137a025 |
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Synthesis and pharmacological evaluation of poly(oxyethylene) derivatives of 4-isobutylphenyl-2-propionic acid (ibuprofen) R. Cecchi, L. Rusconi, M. C. Tanzi, F. Danusso, and P. Ferruti pp 622 - 625; DOI: 10.1021/jm00137a026 |
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Azaprostaglandin analogs. Synthesis and biological properties of 11-azaprostaglandin derivatives Achille Barco, Simonetta Benetti, Gian Piero Pollini, Pier Giovanni Baraldi, Mario Guarneri, Carmelo Gandolfi, Roberto Ceserani, and Daniela Longiave pp 625 - 628; DOI: 10.1021/jm00137a027 |
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Approaches to vasodilating/.beta.-adrenergic blocking agents: examples of the dihydrolutidine type John J. Baldwin, R. Hirschmann, Edward L. Engelhardt, Gerald S. Ponticello, Charles S. Sweet, and A. Scriabine pp 628 - 631; DOI: 10.1021/jm00137a028 |
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Synthesis and antiinflammatory activity of 2,2'-diaminobiphenyl derivatives Romano Calcinari, Nadia Case, Alfredo Guerrato, Roberto Milanino, Elda Passarella, Michele Perchinunno, Bruno Tamburini, and Fabio Sparatore pp 632 - 634; DOI: 10.1021/jm00137a029 |
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Erythro-5-[1-hydroxy-2-(isopropylamino)butyl]-7-hydroxycarbostyril, a terbutaline-type derivative of the bronchodilator procaterol Yasumitsu Tamura, Shiro Yoshizaki, and Kouzo Watanabe pp 634 - 636; DOI: 10.1021/jm00137a030 |
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Toxicity and quantitative structure-activity relationships of colchicines Frank R. Quinn, Zohar Neiman, and John A. Beisler pp 636 - 639; DOI: 10.1021/jm00137a031 |
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Preparation and antibacterial activity of .DELTA.1-thienamycin David H. Shih and Ronald W. Ratcliffe pp 639 - 643; DOI: 10.1021/jm00137a032 |
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Book Reviews pp 643 - 650; DOI: 10.1021/jm00137a600 |
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Perspectives for the use of collagen synthesis inhibitors as antifibrotic agents George C. Fuller pp 651 - 658; DOI: 10.1021/jm00138a001 |
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Mesoionic xanthine analogs: phosphodiesterase inhibitory and hypotensive activity Richard A. Glennon, Michael E. Rogers, J. Doyle Smith, M. K. El-Said, and John L. Egle pp 658 - 661; DOI: 10.1021/jm00138a002 |
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Cyclic urea nucleosides. Cytidine deaminase activity as a function of aglycon ring size Paul S. Liu, Victor E. Marquez, John S. Driscoll, Richard W. Fuller, and John J. McCormack pp 662 - 666; DOI: 10.1021/jm00138a003 |
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Mammalian metabolism of phencyclidine John K. Baker, James G. Wohlford, Barton J. Bradbury, and Philip W. Wirth pp 666 - 669; DOI: 10.1021/jm00138a004 |
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Synthesis and preliminary antitumor evaluation of 5-iminodoxorubicin Edward M. Acton and George L. Tong pp 669 - 673; DOI: 10.1021/jm00138a005 |
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Synthesis and antitumor activity of cysteinyl-3,4-dihydroxyphenylalonines and related compounds Shosuke Ito, Shigeki Inoue, Yoshinobu Yamamoto, and Keisuke Fujita pp 673 - 677; DOI: 10.1021/jm00138a006 |
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Synthesis and evaluation of novel alkylpiperazines as potential dopamine antagonists Richard A. Glennon, John J. Salley, Odd S. Steinsland, and Sharon Nelson pp 678 - 683; DOI: 10.1021/jm00138a007 |
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Synthesis and pharmacological evaluation of sulfonium analogs of dopamine: nonclassical dopamine agonists Karen Anderson, Alice Kuruvilla, Norman Uretsky, and Duane D. Miller pp 683 - 687; DOI: 10.1021/jm00138a008 |
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An approach to the elucidation of metabolic breakdown products of the luteinizing hormone-releasing hormone Mary Alice Stetler-Stevenson, Dai Chang Yang, Andrew Lipkowski, Linda McCartney, Darryl Peterson, and George Flouret pp 688 - 692; DOI: 10.1021/jm00138a009 |
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Synthesis of thyrotropin-releasing hormone analogs with selective central nervous system effects Ruth F. Nutt, Frederick W. Holly, Carl Homnick, Ralph Hirschmann, Daniel F. Veber, and Byron H. Arison pp 692 - 698; DOI: 10.1021/jm00138a010 |
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Inactivation of trypsin-like proteases by depsipeptides of p-guanidinobenzoic acid Vishwas S. Ganu and Elliott Shaw pp 698 - 700; DOI: 10.1021/jm00138a011 |
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Synthetic antagonists of in vivo antidiuretic and vasopressor responses to arginine-vasopressin Maurice Manning, Bernard Lammek, Alexander M. Kolodziejczyk, J. Seto, and W. H. Sawyer pp 701 - 706; DOI: 10.1021/jm00138a012 |
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Synthesis of peptide analogs of prothrombin precursor sequence 5-9. Substrate specificity of vitamin K dependent carboxylase Daniel H. Rich, S. Russ Lehrman, Megumi Kawai, Hedda L. Goodman, and John W. Suttie pp 706 - 711; DOI: 10.1021/jm00138a013 |
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Synthesis and preliminary pharmacological evaluation of asymmetric chloroquine analogs Donald T. Witiak, David A. Grattan, Richard J. Heaslip, and Ralf G. Rahwan pp 712 - 717; DOI: 10.1021/jm00138a014 |
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Analgesic narcotic antagonists. 5. 7,7-Dimethyldihydrocodeinones and 7,7-dimethyldihydromorphinones David L. Leland and Michael P. Kotick pp 717 - 721; DOI: 10.1021/jm00138a015 |
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Analgesic narcotic antagonists. 6. 7.beta.,8.beta.-Methano- and 7.beta.,8.beta.-epoxydihydrocodeinone Michael P. Kotick pp 722 - 726; DOI: 10.1021/jm00138a016 |
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Synthesis and anticonvulsant activity of N-(benzoylalkyl)imidazoles and N-(.omega.-phenyl-.omega.-hydroxyalkyl)imidazoles Dante Nardi, Alberto Tajana, Amedeo Leonardi, Renzo Pennini, Ferruccio Portioli, Maria Jose Magistretti, and Alessandro Subissi pp 727 - 731; DOI: 10.1021/jm00138a017 |
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Synthesis and antiherpetic activity of some 4-[(aryloxy)alkyl]pyrazoles Guy D. Diana, Philip M. Carabateas, Gordon L. Williams, Francis Pancic, and Bernard A. Steinberg pp 731 - 735; DOI: 10.1021/jm00138a018 |
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Pyrazolo[5,1-b]quinazolin-9-ones: a new series of antiallergic agents Jagadish C. Sircar, Thomas Capiris, Stephen J. Kesten, and David J. Herzig pp 735 - 742; DOI: 10.1021/jm00138a019 |
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N-(Aminophenyl)oxamic acids and esters as potent, orally active antiallergy agents Dieter H. Klaubert, John H. Sellstedt, Charles J. Guinosso, Robert J. Capetola, and Stanley C. Bell pp 742 - 748; DOI: 10.1021/jm00138a020 |
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5-Tetrazolecarboxamides and their salts: new orally active antiallergy agents Dieter H. Klaubert, John H. Sellstedt, Charles J. Guinosso, Stanley C. Bell, and Robert J. Capetola pp 748 - 752; DOI: 10.1021/jm00138a021 |
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Pyrimidine acyclic nucleosides. 1-[(2-Hydroxyethoxy)methyl]pyrimidines as candidate antivirals James L. Kelley, John E. Kelsey, William R. Hall, Mark P. Krochmal, and Howard J. Schaeffer pp 753 - 756; DOI: 10.1021/jm00138a022 |
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Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 3. Bis[tetrahydroisoquinoline]s R. M. DeMarinis, W. M. Bryan, L. M. Hillegass, D. McDermott, and R. G. Pendleton pp 756 - 759; DOI: 10.1021/jm00138a023 |
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Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine A. Stanley Jones, S. George Rahim, Richard T. Walker, and Erik De Clercq pp 759 - 760; DOI: 10.1021/jm00138a024 |
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Metabolism of 1,3-bis(2-chloroethyl)-1-nitrosourea by rat hepatic microsomes Huey-Shin Lin and Robert J. Weinkam pp 761 - 763; DOI: 10.1021/jm00138a025 |
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Nitrogen-13-labeled L-amino acids for in vivo assessment of local myocardial metabolism Fritz J. Baumgartner, Jorge R. Barrio, Eberhard Henze, Heinrich R. Schelbert, Norman S. MacDonald, Michael E. Phelps, and David E. Kuhl pp 764 - 766; DOI: 10.1021/jm00138a026 |
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Benz-fused mesoionic xanthine analogs as inhibitors of cyclic-AMP phosphodiesterase Richard A. Glennon, Judith J. Gaines, and Michael E. Rogers pp 766 - 769; DOI: 10.1021/jm00138a027 |
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Book Reviews pp 769 - 772; DOI: 10.1021/jm00138a600 |
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6-Demethoxythebaine and its conversion to analgesics of the 6,14-ethenomorphinan type Charles W. Hutchins, Geoffrey K. Cooper, Serge Puerro, and Henry Rapoport pp 773 - 777; DOI: 10.1021/jm00139a002 |
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Opiate receptor interaction of compounds derived from or structurally related to fentanyl Marinus W. Lobbezoo, Willem Soudijn, and Ineke Van Wijngaarden pp 777 - 782; DOI: 10.1021/jm00139a003 |
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Allylprodine analogs as receptor probes. Evidence that phenolic and nonphenolic ligands interact with different subsites on identical opioid receptors Philip S. Portoghese, Bipin D. Alreja, and Dennis L. Larson pp 782 - 787; DOI: 10.1021/jm00139a004 |
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Epimeric cis-decahydroquinoline-5-carboxylic acids: effects on .gamma.-aminobutyric acid uptake and receptor binding in vitro Donald T. Witiak, Kuniyuki Tomita, Raymond J. Patch, and S. J. Enna pp 788 - 794; DOI: 10.1021/jm00139a005 |
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Potential pancreatic imaging agents. Tellurium-123m labeled-DL-.alpha.-amino-.gamma.-(phenyltelluro)butyric acid Furn F. Knapp, Kathleen R. Ambrose, and Alvin P. Callahan pp 794 - 797; DOI: 10.1021/jm00139a006 |
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New antiarrhythmic agents. 6. Quantitative structure-activity relationships of aminoxylidides Paul A. Tenthorey, Alan J. Block, Robert A. Ronfeld, Paul D. McMaster, and Eugene W. Byrnes pp 798 - 806; DOI: 10.1021/jm00139a007 |
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Methylangelicins: new potential agents for the photochemotherapy of psoriasis. Structure-activity study on the dark and photochemical interactions with DNA Francesco Dall'Acqua, Daniela Vedaldi, Adriano Guiotto, Paolo Rodighiero, Francesco Carlassare, Francarosa Baccichetti, and Franco Bordin pp 806 - 811; DOI: 10.1021/jm00139a008 |
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Inhibition of dihydrofolate reductase: structure-activity correlations of quinazolines based upon molecular shape analysis Carol Battershell, D. Malhotra, and A. J. Hopfinger pp 812 - 818; DOI: 10.1021/jm00139a009 |
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Inhibition of dihydrofolate reductase: structure-activity correlations of 2,4-diamino-5-benzylpyrimidines based upon molecular shape analysis A. J. Hopfinger pp 818 - 822; DOI: 10.1021/jm00139a010 |
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Effects of 1-arylpyrroles and naphthoflavones upon cytochrome P-450 dependent monooxygenase activities Tito Viswanathan and W. L. Alworth pp 822 - 830; DOI: 10.1021/jm00139a011 |
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Novel immunosuppressive agents. Potent immunological activity of some benzothiopyrano[4,3-c]pyrazol-3-ones Joseph G. Lombardino and Ivan G. Otterness pp 830 - 834; DOI: 10.1021/jm00139a012 |
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N-Aralkyl substitution of 2-amino-5,6- and -6,7-dihydroxy-1,2,3,4-tetrahydronaphthalenes. 1. Cardiac and pressor/depressor activities Richard J. Gorczynski, William G. Anderson, and David M. Stout pp 835 - 839; DOI: 10.1021/jm00139a013 |
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Synthesis and biological evaluation of the methyl esters of (+)-12-fluoro-13,14-dihydroprostaglandin F2.alpha. and (+)-15-epi-12-fluoro-13,14-dihydroprostaglandin F2.alpha. Paul A. Grieco and Tetsuo Takigawa pp 839 - 843; DOI: 10.1021/jm00139a014 |
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A nonmetabolized analog of phenytoin James D. Henderson, Peter G. Dayton, Zafar H. Israili, and Leon Mandell pp 843 - 847; DOI: 10.1021/jm00139a015 |
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Haloacetamido analogs of 2-amino-2-deoxy-D-mannose. Syntheses and effects on tumor-bearing mice Thomas P. Fondy and Cheryl A. Emlich pp 848 - 852; DOI: 10.1021/jm00139a016 |
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Synthesis and antitumor activity of a series of sulfone analogs of 1,4-naphthoquinone Mark H. Holshouser, Larry J. Loeffler, and Iris H. Hall pp 853 - 858; DOI: 10.1021/jm00139a017 |
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Comparison of mutagenic and carcinogenic activities of aniline mustards Albert Leo, Augustine Panthananickal, Corwin Hansch, Jeffrey Theiss, Michael Shimkin, and A. W. Andrews pp 859 - 864; DOI: 10.1021/jm00139a018 |
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(Acylaryloxy)acetic acid diuretics. 3. 2,3-Dihydro-5-acyl-2-benzofurancarboxylic acids, a new class of uricosuric diuretics William F. Hoffman, Otto W. Woltersdorf, Frederick C. Novello, Edward J. Cragoe, James P. Springer, L. Sherman Watson, and George M. Fanelli pp 865 - 873; DOI: 10.1021/jm00139a019 |
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(Acylaryloxy)acetic acid diuretics. 4. Indeno[5,4-b]furan-2-carboxylic acids Otto W. Woltersdorf, S. Jane deSolms, and Edward J. Cragoe pp 874 - 878; DOI: 10.1021/jm00139a020 |
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Synthesis and antiallergy activity of 4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidines Francis J. Tinney, Wiaczeslaw A. Cetenko, Joseph J. Kerbleski, David T. Connor, Roderick J. Sorenson, and David J. Herzig pp 878 - 882; DOI: 10.1021/jm00139a021 |
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Synthesis and serotonin-like activity of 2-amino-5,8-dimethoxy-6-methyl-1,2-dihydronaphthalene Paresh J. Kothari, Bruce A. Hathaway, David E. Nichols, and George K. W. Yim pp 882 - 884; DOI: 10.1021/jm00139a022 |
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Synthesis of Ala-Pro-Gly-[Ile3,Val5]angiotensin II isolated from the skin of the Australian frog Crinia georgiana M. C. Khosla, F. M. Bumpus, T. Yasuhara, and T. Nakajima pp 885 - 887; DOI: 10.1021/jm00139a023 |
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Synthesis of 5'-thymidinyl bis(1-aziridinyl)phosphinates as antineoplastic agents Luke Y. Hsiao and Thomas J. Bardos pp 887 - 889; DOI: 10.1021/jm00139a024 |
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(Phenylthio)phenylamine derivatives as potential antiinflammatory compounds A. Marcincal-Lefebvre, J. C. Gesquiere, C. Lemer, and B. Dupuis pp 889 - 893; DOI: 10.1021/jm00139a025 |
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Nucleosides. 114. 5'-O-Glucuronides of 5-fluorouridine and 5-fluorocytidine. Masked precursors of anticancer nucleosides K. A. Watanabe, A. Matsuda, M. J. Halat, D. H. Hollenberg, J. S. Nisselbaum, and J. J. Fox pp 893 - 897; DOI: 10.1021/jm00139a026 |
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Aporphines. 34. (-)-2,10,11-Trihydroxy-N-n-propylnoraporphine, a novel dopaminergic aporphine alkaloid with anticonvulsant activity J. L. Neumeyer, S. J. Law, B. Meldrum, G. Anlezark, and K. J. Watling pp 898 - 899; DOI: 10.1021/jm00139a027 |
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Compatibility of the Free-Wilson and Hansch quantitative structure-activity relations L. J. Schaad, B. A. Hess, W. P. Purcell, A. Cammarata, R. Franke, and H. Kubinyi pp 900 - 901; DOI: 10.1021/jm00139a028 |
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Synthesis and evaluation of the male antifertility properties of a series of N-unsubstituted sulfamates Allen F. Hirsch, Charles Kasulanis, Larry Kraft, Robert A. Mallory, Gregory Powell, and Benny Wong pp 901 - 903; DOI: 10.1021/jm00139a029 |
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Synthesis of analogs of acetylmethadol and methadol as potential narcotic antagonists Danny L. Lattin, Bill Caviness, Rick G. Hudson, David L. Greene, Pamela K. Raible, and J. Blake Richardson pp 903 - 906; DOI: 10.1021/jm00139a030 |
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Studies on phenethylamine hallucinogens. 2. Conformations of arylmethoxyl groups by carbon-13 NMR James J. Knittel and Alexandros Makriyannis pp 906 - 909; DOI: 10.1021/jm00139a031 |
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Book Reviews pp 909 - 912; DOI: 10.1021/jm00139a600 |
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1980 Award in medicinal chemistry. Medicinal chemistry and dynamic structure-activity analysis in the discovery of drugs acting at histamine H2 receptors Robin Ganellin pp 913 - 920; DOI: 10.1021/jm00140a001 |
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8-Hydroxy-2-(dipropylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist Lars Erik Arvidsson, Uli Hacksell, J. Lars G. Nilsson, Stephan Hjorth, Arvid Carlsson, Per Lindberg, Domingo Sanchez, and Haakan Wikstroem pp 921 - 923; DOI: 10.1021/jm00140a002 |
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Antitumor agents. 44. Bis(helenalinyl) esters and related derivatives as novel potent antileukemic agents Kuo-Hsiung Lee, Toshiro Ibuka, Donald Sims, Osamu Muraoka, Hiroshi Kiyokawa, Iris H. Hall, and Hyeong L. Kim pp 924 - 927; DOI: 10.1021/jm00140a003 |
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Gastric antisecretory agents. 1. Antisecretory and antiulcer activity of 5H-[1]benzopyrano[2,3-b]pyridin-5-ylureas and 5H-[1]benzothiopyrano[2,3-b]pyridin-5-ylureas James A. Bristol, Elijah H. Gold, Raymond G. Lovey, and James F. Long pp 927 - 932; DOI: 10.1021/jm00140a004 |
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2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 5. 3',5'-Dimethoxy-4'-substituted-benzyl analogs of trimethoprim Barbara Roth, Edward Aig, Barbara S. Rauckman, Justina Z. Strelitz, Arthur P. Phillips, Robert Ferone, S. R. M. Bushby, and Carl W. Sigel pp 933 - 941; DOI: 10.1021/jm00140a005 |
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Synthesis and antiviral activity of certain 9-.beta.-D-ribofuranosylpurine-6-carboxamides James D. Westover, Ganapathi R. Revankar, Roland K. Robins, Randall D. Madsen, John R. Ogden, James A. North, Robert W. Mancuso, Robert J. Rousseau, and Edward L. Stephen pp 941 - 946; DOI: 10.1021/jm00140a006 |
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Synthesis and pharmacological evaluation of a series of analogs of 1-methylisoguanosine Robert T. Bartlett, Alan F. Cook, Michael J. Holman, Warren W. McComas, Eugene F. Nowoswait, Mohindar S. Poonian, Judy A. Baird-Lambert, Brian A. Baldo, and John F. Marwood pp 947 - 954; DOI: 10.1021/jm00140a007 |
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Inhibition of separated forms of cyclic nucleotide phosphodiesterase from pig coronary arteries by 1,3-disubstituted and 1,3,8-trisubstituted xanthines Jack N. Wells, John E. Garst, and George L. Kramer pp 954 - 958; DOI: 10.1021/jm00140a008 |
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Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 3. 5-(Arylthio)-, 5-(arylsulfinyl)-, and 5-(arylsulfonyl)thiophene-2-sulfonamides Ian T. Barnish, Peter E. Cross, Roger P. Dickinson, Michael J. Parry, and Michael J. Randall pp 959 - 964; DOI: 10.1021/jm00140a009 |
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Novel synthesis of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline and analogs: potent angiotensin converting enzyme inhibitors Robert F. Meyer, Ernest D. Nicolaides, Francis G. Tinney, Elizabeth A. Lunney, Ann Holmes, Milton L. Hoefle, Ronald D. Smith, Arnold D. Essenburg, Harvey R. Kaplan, and Ronald G. Almquist pp 964 - 969; DOI: 10.1021/jm00140a010 |
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Selective and potent .beta.2-adrenoceptor agents within the tetrahydroisoquinoline class: effect of methyl substitution at the benzylic carbon of the 1-(3,4,5-trimethoxybenzyl) group of trimetoquinol Douglas J. Sober, Jane Chang, Edward H. Fairchild, John W. Fowble, Asoke Mukhopadhyay, Dennis R. Feller, and Duane D. Miller pp 970 - 974; DOI: 10.1021/jm00140a011 |
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Development of new mitomycin C and porfiromycin analogs Bhashyam S. Iyengar, Horng-Jau Lin, Leung Cheng, William A. Remers, and William T. Bradner pp 975 - 981; DOI: 10.1021/jm00140a012 |
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Pyrazolodiazepines. III. 4-Aryl-1,6,7,8-tetrahydro-1,3-dialkylpyrazolo[3,4-e][1,4]diazepines as antidepressant agents H. A. DeWald, S. Lobbestael, and B. P. H. Poschel pp 982 - 987; DOI: 10.1021/jm00140a013 |
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N-Hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen Ian C. Calder, Sandra J. Hart, Kevin Healey, and Kathryn N. Ham pp 988 - 993; DOI: 10.1021/jm00140a014 |
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2-Benzodioxinylaminoethanol: a new class of .beta.-adrenergic blocking and antihypertensive agents Lucien Lalloz, Vincent Loppinet, Gerard Coudert, Gerald Guillaumet, Bernard Loubinoux, Claude Labrid, Michele Beaughard, Georges Dureng, and Jean Claude Lamar pp 994 - 998; DOI: 10.1021/jm00140a015 |
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2-(Arylmethyl)arylacetic acids as potential antiinflammatory agents Giovanni Brancaccio, Angelo Larizza, Guglielmo Lettieri, and Pietro Monforte pp 998 - 1000; DOI: 10.1021/jm00140a016 |
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Antimalarial drugs. 50. Folate antagonists. 19. Synthesis and antimalarial effects of 6-(arylthio)-2,4-pteridinediamines Edward F. Elslager, Judith L. Johnson, and Leslie M. Werbel pp 1001 - 1003; DOI: 10.1021/jm00140a017 |
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Diuretic agents related to indapamide. 1. Synthesis and activity of 1-substituted 2-(4-chloro-3-sulfamoylbenzamido)isoindolines Giorgio Cignarella, Paolo Sanna, Egidio Miele, Vittorio Anania, and Maria S. Desole pp 1003 - 1006; DOI: 10.1021/jm00140a018 |
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Nonsteroidal antiinflammatory agents. 3. Synthesis of the positional isomers of 4'-chloro-5-methoxy-3-biphenylylacetic acid and their antiinflammatory and analgesic activities Yasumitsu Tamura, Yoshihiko Yoshimoto, Shinichi Tada, Katsutoshi Kunimoto, Shingo Matsumura, Masao Murayama, Yoshihisa Shibata, and Hiroshi Enomoto pp 1006 - 1010; DOI: 10.1021/jm00140a019 |
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Gastric antisecretory agents. 2. Antisecretory activity of 9-[(aminoalkyl)thio]-9H-xanthenes and 5-[(aminoalkyl)thio]-5H-[1]benzopyrano[2,3-b]pyridines James A. Bristol, Elijah H. Gold, Irwin Gross, Raymond G. Lovey, and James F. Long pp 1010 - 1013; DOI: 10.1021/jm00140a020 |
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Dopamine agonist properties of N-alkyl-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines James N. Jacob, David E. Nichols, Jai D. Kohli, and Dana Glock pp 1013 - 1015; DOI: 10.1021/jm00140a021 |
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Syntheses of 9-acridine- and 2-phenanthridinemethanols as potential antimalarials Chester W. Muth, Howard L. Minigh, Suchart Chookruvong, Larry A. Hall, and Hung-Tai Chao pp 1016 - 1018; DOI: 10.1021/jm00140a022 |
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Book Reviews pp 1018 - 1020; DOI: 10.1021/jm00140a600 |
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Synthesis of clozapine analogs and their affinity for clozapine and spiroperidol binding sites in rat brain Tomas De Paulis, C. Ross Betts, Howard E. Smith, Philip L. Mobley, D. Hal Manier, and Fridolin Sulser pp 1021 - 1026; DOI: 10.1021/jm00141a001 |
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Dopamine receptor model and its application in the design of a new class of rigid pyrrolo[2,3-g]isoquinoline antipsychotics Gary L. Olson, Ho-Chuen Cheung, Keith D. Morgan, John F. Blount, Louis Todaro, Leo Berger, Arnold B. Davidson, and Edward Boff pp 1026 - 1034; DOI: 10.1021/jm00141a002 |
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Inhibition of cholesterol side-chain cleavage. 3. 22-Azacholesterol analogs bearing aryl-substituted side chains Norma G. Delaney and Matthias C. Lu pp 1034 - 1038; DOI: 10.1021/jm00141a003 |
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Inhibition of cholesterol side-chain cleavage. 4. Synthesis of A or B ring-modified azacholesterols Matthias C. Lu, Norma G. Delaney, and Raymond E. Counsell pp 1038 - 1042; DOI: 10.1021/jm00141a004 |
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Synthesis of fluorine-containing peptides. Analogs of angiotensin II containing hexafluorovaline William H. Vine, Kun-Hwa Hsieh, and Garland R. Marshall pp 1043 - 1047; DOI: 10.1021/jm00141a005 |
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Phencyclidine metabolism: resolution, structure, and biological activity of the isomers of the hydroxymetabolite, 4-phenyl-4-(1-piperidinyl)cyclohexanol F. Ivy Carroll, George A. Brine, Karl G. Boldt, Edward J. Cone, David Yousefnejad, D. Bruce Vaupel, and William F. Buchwald pp 1047 - 1051; DOI: 10.1021/jm00141a006 |
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N2- and C-7-Substituted actinomycin D analogs: synthesis, DNA-binding affinity, and biochemical and biological properties. Structure-activity relationship Sisir K. Sengupta, Jerome E. Anderson, Yury Kogan, Dorothy H. Trites, William R. Beltz, and Madulla S. Madhavarao pp 1052 - 1059; DOI: 10.1021/jm00141a007 |
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New antiarrhythmic agents. 7. 2,3-Diaminopropionanilides Paul A. Tenthorey, H. Jack Adams, George H. Kronberg, and Bertil H. Takman pp 1059 - 1063; DOI: 10.1021/jm00141a008 |
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2-(Aminomethyl)phenols, a new class of saluretic agents. 3. Effects of functional group reorientation and modification G. E. Stokker, A. A. Deana, S. J. DeSolms, E. M. Schultz, R. L. Smith, E. J. Cragoe, J. E. Baer, H. F. Russo, and L. S. Watson pp 1063 - 1067; DOI: 10.1021/jm00141a009 |
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Folate analogs altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds M. G. Nair, Timothy W. Bridges, Timothy J. Henkel, Roy L. Kisliuk, Y. Gaumont, and F. M. Sirotnak pp 1068 - 1073; DOI: 10.1021/jm00141a010 |
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Antimicrobial 3-methylene flavanones Frederick E. Ward, David L. Garling, Robert T. Buckler, David M. Lawler, and Dennis P. Cummings pp 1073 - 1077; DOI: 10.1021/jm00141a011 |
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Synthesis and biological effects of acyclic pyrimidine nucleoside analogs Alan C. Schroeder, Robert G. Hughes, and Alexander Bloch pp 1078 - 1083; DOI: 10.1021/jm00141a012 |
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Carbocyclic analogs of 5-fluorouracil nucleosides Y. Fulmer Shealy, Jerry L. Frye, Nancy F. DuBois, Sue C. Shaddix, and R. Wallace Brockman pp 1083 - 1086; DOI: 10.1021/jm00141a013 |
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Synthesis of 5,11-methenyltetrahydrohomofolate and its antifolate activity in vitro Carol A. Caperelli, Paul Domanico, and Stephen J. Benkovic pp 1086 - 1088; DOI: 10.1021/jm00141a014 |
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Cyclic urea and thiourea derivatives as inducers of murine erythroleukemia differentiation Chau-Der Li, Sharon L. Mella, and Alan C. Sartorelli pp 1089 - 1092; DOI: 10.1021/jm00141a015 |
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Induction of differentiation of leukemia cells in vitro by N-substituted amides, lactams, and 2-pyridones Chau-Der Li, Edward L. Schwartz, Sharon L. Mella, Lana S. Rittmann, and Alan C. Sartorelli pp 1092 - 1094; DOI: 10.1021/jm00141a016 |
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Potential histamine H2-receptor blockers. 3- and 2-Indole derivatives as immobile analogs of tautomeric forms of cimetidine Haile Tecle, Lillian Robichaud, and Charles F. Schwender pp 1095 - 1097; DOI: 10.1021/jm00141a017 |
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Antiinflammatory 5,6-dihydro-11-oxodibenz[b,e]azepine-3-acetic acids James P. Dunn, Joseph M. Muchowski, and Peter H. Nelson pp 1097 - 1099; DOI: 10.1021/jm00141a018 |
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Inhibition of liver alanine aminotransferase activity by some benzophenanthridine alkaloids Daniela Walterova, Jitka Ulrichova, Vladimir Preininger, Vilim Simanek, Jiri Lenfeld, and Jan Lasovsky pp 1100 - 1103; DOI: 10.1021/jm00141a019 |
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Structure-activity relationship study of spirolactones. Contribution of the cyclopropane ring to antimineralocorticoid activity Leland J. Chinn, Karlene W. Salamon, and Bipin N. Desai pp 1103 - 1107; DOI: 10.1021/jm00141a020 |
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Synthesis and evaluation of 1,2,3,4-tetrahydro[1]benzothieno[2,3-h]isoquinolines as dopamine antagonists Charles R. Ellefson and Kathleen A. Prodan pp 1107 - 1110; DOI: 10.1021/jm00141a021 |
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Book Reviews pp 1110 - 1112; DOI: 10.1021/jm00141a600 |
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Future directions in dopaminergic nervous system and dopaminergic agonists Joseph G. Cannon, John Paul Long, and Ranbir Bhatnagar pp 1113 - 1118; DOI: 10.1021/jm00142a001 |
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Evidence of the preferential involvement of .mu.-receptors in analgesia using enkephalins highly selective for peripheral .mu. or .delta. receptors Gilles Gacel, Marie Claude Fournie-Zaluski, Etienne Fellion, and Bernard P. Roques pp 1119 - 1124; DOI: 10.1021/jm00142a002 |
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Nonquaternary cholinesterase reactivators. Dialkylaminoalkyl thioesters of .alpha.-ketothiohydroximic acids as reactivators of diisopropyl phosphorofluoridate-inhibited acetylcholinesterase Richard A. Kenley, Robert A. Howd, Carol W. Mosher, and John S. Winterle pp 1124 - 1133; DOI: 10.1021/jm00142a003 |
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Trapping of metabolically generated electrophilic species with cyanide ion: metabolism of methapyrilene R. Ziegler, Bert Ho, and N. Castagnoli pp 1133 - 1138; DOI: 10.1021/jm00142a004 |
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Highly selective inhibitors of thromboxane synthetase. 1. Imidazole derivatives Kinji Iizuka, Kenji Akahane, Denichi Momose, Masayuki Nakazawa, Tadao Tanouchi, Masanori Kawamura, Isao Ohyama, Ikuo Kajiwara, Yohichi Iguchi, and et al. pp 1139 - 1148; DOI: 10.1021/jm00142a005 |
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Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives Tadao Tanouchi, Masamori Kawamura, Isao Ohyama, Ikuo Kajiwara, Yohichi Iguchi, Takanori Okada, Tsumoru Miyamoto, Ken Taniguchi, Masaki Hayashi, and et al. pp 1149 - 1155; DOI: 10.1021/jm00142a006 |
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Inhibition of inosinic acid dehydrogenase by 8-substituted purine nucleotides Edward B. Skibo and Rich B. Meyer pp 1155 - 1161; DOI: 10.1021/jm00142a007 |
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Interaction of 1-(5-phospho-.beta.-D-arabinofuranosyl)-5-substituted-uracils with thymidylate synthetase: mechanism-based inhibition by 1-(5-phospho-.beta.-D-arabinofurosyl)-5-fluorouracil Chikao Nakayama, Yusuke Wataya, Daniel V. Santi, Mineo Saneyoshi, and Tohru Ueda pp 1161 - 1165; DOI: 10.1021/jm00142a008 |
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Pyrazolopyrimidine nucleosides. 12. Synthesis and biological activity of certain pyrazolo[3,4-d]pyrimidine nucleosides related to adenosine Ganapati A. Bhat, Jean Louis G. Montero, Raymond P. Panzica, Linda L. Wotring, and Leroy B. Townsend pp 1165 - 1172; DOI: 10.1021/jm00142a009 |
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Synthesis and biological activity of certain derivatives of oxazinomycin and related oxadiazole nucleosides Prem C. Srivastava and Roland K. Robins pp 1172 - 1177; DOI: 10.1021/jm00142a010 |
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Synthesis and antitumor activity of an acyclonucleoside derivative of 5-fluorouracil Andre Rosowsky, Sun-Hyuk Kim, and Michael Wick pp 1177 - 1181; DOI: 10.1021/jm00142a011 |
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N*-N*-S* Tridentate ligand system as potential antitumor agents Ippolito Antonini, Francesco Claudi, Gloria Cristalli, Palmarisa Franchetti, Mario Grifantini, and Sante Martelli pp 1181 - 1184; DOI: 10.1021/jm00142a012 |
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Synthesis and antineoplastic activity of mitosene analogs of the mitomycins John C. Hodges, William A. Remers, and William T. Bradner pp 1184 - 1191; DOI: 10.1021/jm00142a013 |
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Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes Rolf W. Hartmann, Helga Buchborn, Gerhard Kranzfelder, Helmut Schoenenberger, and Arthur E. Bogden pp 1192 - 1197; DOI: 10.1021/jm00142a014 |
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Membrane effects of antiinflammatory agents. 1. Interaction of sulindac and its metabolites with phospholipid membrane, a magnetic resonance study Sophie S. Fan and T. Y. Shen pp 1197 - 1202; DOI: 10.1021/jm00142a015 |
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Membrane effects of antiinflammatory agents. 2. Interaction of nonsteroidal antiinflammatory drugs with liposome and purple membranes San-Bao Hwang and T. Y. Shen pp 1202 - 1211; DOI: 10.1021/jm00142a016 |
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.beta.-Adrenergic blocking agents. .alpha.- and .gamma.-Methyl(aryloxy)propanolamines Thomas L. Lemke, Michael B. Cramer, Stanley W. Adamski, Carolyn A. Pedone, and Gary Brooker pp 1211 - 1214; DOI: 10.1021/jm00142a017 |
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Retinoic acid analogs with ring modifications. Synthesis and pharmacological activity Marcia I. Dawson, Peter D. Hobbs, Rebecca L. S. Chan, and Wan-Ru Chao pp 1214 - 1223; DOI: 10.1021/jm00142a018 |
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Synthesis and neuroleptic activity of benzamides. cis-N-(1-Benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide and related compounds Sumio Iwanami, Mutsuo Takashima, Yasufumi Hirata, Osamu Hasegawa, and Shinji Usuda pp 1224 - 1230; DOI: 10.1021/jm00142a019 |
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A new nontricyclic antidepressant agent. Synthesis and activity of N-[trans-2-dimethylaminocyclopentyl]-N-(3,4-dichlorophenyl)propanamide and related compounds J. Szmuszkovicz, P. F. VonVoigtlander, and M. P. Kane pp 1230 - 1236; DOI: 10.1021/jm00142a020 |
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Synthesis and pharmacology of hydroxylated metabolites of methyl phenidate Kennerly S. Patrick, Clinton D. Kilts, and George R. Breese pp 1237 - 1240; DOI: 10.1021/jm00142a021 |
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Synthesis and pharmacological activity of thiohexital enantiomers F. Ivy Carroll, Abraham Philip, D. Mark Naylor, H. Dix Christensen, and W. C. Goad pp 1241 - 1244; DOI: 10.1021/jm00142a022 |
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Potential salicylamide antiplaque agents: in vitro antibacterial activity against Actinomyces viscosus Robert A. Coburn, Armando J. Batista, Richard T. Evans, and Robert J. Genco pp 1245 - 1249; DOI: 10.1021/jm00142a023 |
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Synthesis and evaluation of ureido and vinylureidopenicillins as inhibitors of intraruminal lactic acid production Robin D. Clark, Joan M. Caroon, Ian T. Harrison, Arthur F. Kluge, Stefan H. Unger, Howard R. Spires, and Thomas R. Mathews pp 1250 - 1253; DOI: 10.1021/jm00142a024 |
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New synthesis of N-[4-[[(2-amino-4(3H)-oxopyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamic acid (8-deazafolic acid) and the preparation of some 5,6,7,8-tetrahydro derivatives Carroll Temple, C. L. Kussner, J. D. Rose, D. L. Smithers, L. L. Bennett, and J. A. Montgomery pp 1254 - 1258; DOI: 10.1021/jm00142a025 |
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Synthesis and adrenoceptor affinity of some highly polar .beta.-substituted catecholamines James G. Henkel, Neil Sikand, Alexandros Makriyannis, and Gerald Gianutsos pp 1258 - 1260; DOI: 10.1021/jm00142a026 |
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(.alpha.S)-erythro-.alpha.-Methylepinephrine: preparation and stereoselective binding to adrenergic receptors in rat forebrain Clinton A. Taylor, Howard E. Smith, Michael R. Goldberg, and David Robertson pp 1261 - 1263; DOI: 10.1021/jm00142a027 |
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A novel approach for heavy metal poisoning treatment, a model. Mercury poisoning by means of chelating microspheres: hemoperfusion and oral administration Shlomo Margel pp 1263 - 1266; DOI: 10.1021/jm00142a028 |
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Book Reviews pp 1267 - 1268; DOI: 10.1021/jm00142a600 |
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Diterpenoid sweeteners. Synthesis and sensory evaluation of stevioside analogs nondegradable to steviol Grant E. DuBois, Paul S. Dietrich, Janice F. Lee, Geoff V. McGarraugh, and Rebecca A. Stephenson pp 1269 - 1271; DOI: 10.1021/jm00143a001 |
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Synthesis and evaluation of some stable multisubstrate adducts as inhibitors of catechol O-methyltransferase Gary L. Anderson, Donald L. Bussolotti, and James K. Coward pp 1271 - 1277; DOI: 10.1021/jm00143a002 |
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Synthesis and evaluation of some stable multisubstrate adducts as specific inhibitors of spermidine synthase Kuo-Chang Tang, Roy Mariuzza, and James K. Coward pp 1277 - 1284; DOI: 10.1021/jm00143a003 |
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Mesoionic purinone analogs as inhibitors of cyclic-AMP phosphodiesterase: comparison of several ring systems Michael E. Rogers, Richard A. Glennon, J. Doyle Smith, Marvin R. Boots, Nitin Nanavati, Julie E. Maconaughey, Debbie Aub, Sheree Thomas, R. G. Bass, and Godwin Mbagwu pp 1284 - 1287; DOI: 10.1021/jm00143a004 |
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Inhibition of human acrosin by monosaccharides and related compounds: structure-activity relationships Robert A. Anderson, Christine Oswald, and Lourens J. D. Zaneveld pp 1288 - 1291; DOI: 10.1021/jm00143a005 |
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2-L-Rhamnopyranosyl[1,2,4]triazolo[1,5-a]pyridine. 4' and 3' Oxidation products. Synthesis and structure-activity relationships Patrice Allard, Tam Huynh Dinh, Catherine Gouyette, Jean Igolen, Jean-Claude Chermann, and Francoise Barre-Sinoussi pp 1291 - 1297; DOI: 10.1021/jm00143a006 |
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Preparation and analgesic properties of amino acid derivatives of (-)-5,9.alpha.-diethyl-2'-hydroxybenzomorphan Patrice C. Belanger, John Scheigetz, Robert N. Young, Stella E. Charleson, Roger L. Hudgin, and Edward L. Engelhardt pp 1297 - 1299; DOI: 10.1021/jm00143a007 |
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Acidic epinephrine analogs derived from 1H,3H-2,1,3-benzothiadiazole 2,2-dioxide and from trifluoromethanesulfonanilide. New synthesis of 1H,3H-2,1,3-benzothiadiazole 2,2-dioxide R. Morrin Acheson, Maris G. Bite, and John E. G. Kemp pp 1300 - 1304; DOI: 10.1021/jm00143a008 |
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Alkylating angiotensin II analogs: Synthesis, analysis, and biological activity of angiotensin II analogs containing the nitrogen mustard melphalan in position 8 Kun-Hwa Hsieh and Garland R. Marshall pp 1304 - 1310; DOI: 10.1021/jm00143a009 |
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Synthesis and antibacterial activity of some esters, amides, and hydrazides of 3-carboxyrifamycin S. Relationship between structure and activity of ansamycins Piero Bellomo, Egidio Marchi, Giuseppe Mascellani, and Mario Brufani pp 1310 - 1314; DOI: 10.1021/jm00143a010 |
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Synthesis and antibacterial activity of 1-(arylamino)-1H-pyrroles and 4-(1H-pyrrol-1-ylimino)-2,5-cyclohexadienes Robert E. Johnson, Albert E. Soria, John R. O'Connor, and Richard A. Dobson pp 1314 - 1319; DOI: 10.1021/jm00143a011 |
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Synthesis and antihypertensive activity of a series of 8-substituted 1-oxa-3,8-diazaspiro[4.5]decan-2-ones Joan M. Caroon, Robin D. Clark, Arthur F. Kluge, Janis T. Nelson, Arthur M. Strosberg, Stefan H. Unger, Anton D. Michel, and Roger L. Whiting pp 1320 - 1328; DOI: 10.1021/jm00143a012 |
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Synthesis and antimetastatic properties of stereoisomeric tricyclic bis(dioxopiperazine) analogs in a B16 melanoma model Donald T. Witiak, Bharat K. Trivedi, Laura B. Campolito, Bruce S. Zwilling, and Nancy A. Reiches pp 1329 - 1332; DOI: 10.1021/jm00143a013 |
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New dimeric analogs of ethidium: synthesis, interaction with DNA, and antitumor activity Karl F. Kuhlmann and Carol W. Mosher pp 1333 - 1337; DOI: 10.1021/jm00143a014 |
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Anticoccidial derivatives of 6-azauracil. 4. A 1000-fold enhancement of potency by phenyl sulfide and phenyl sulfone side chains Max W. Miller, Banavara L. Mylari, Harold L. Howes, Sanford K. Figdor, Martin J. Lynch, John E. Lynch, Shyam K. Gupta, Larry R. Chappel, and Richard C. Koch pp 1337 - 1342; DOI: 10.1021/jm00143a015 |
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Side-chain effects on phenothiazine cation radical reactions Patricia Holt Sackett, J. S. Mayausky, Theresa Smith, Susan Kalus, and Richard L. McCreery pp 1342 - 1347; DOI: 10.1021/jm00143a016 |
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Sulfur analogues of psychotomimetic agents. Monothio analogs of mescaline and isomescaline Peyton Jacob and Alexander T. Shulgin pp 1348 - 1353; DOI: 10.1021/jm00143a017 |
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N-(Methanesulfonyl)-16-phenoxyprostaglandin carboxamides: tissue-selective, uterine stimulants Thomas K. Schaaf, Jasjit S. Bindra, James F. Eggler, Jacob J. Plattner, A. James Nelson, M. Ross Johnson, Jay W. Constantine, Hans-Juergen Hess, and Walter Elger pp 1353 - 1359; DOI: 10.1021/jm00143a018 |
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Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles J. Heeres and J. Van Cutsem pp 1360 - 1364; DOI: 10.1021/jm00143a019 |
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.beta.-Adrenergic blocking agents. 21. Threo-1-(aryloxy)-3-(alkylamino)butan-2-ols Howard Tucker pp 1364 - 1368; DOI: 10.1021/jm00143a020 |
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Structure of a copper-isoniazid complex Jonathan C. Hanson, Norman Camerman, and Arthur Camerman pp 1369 - 1371; DOI: 10.1021/jm00143a021 |
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Book Reviews pp 1371 - 1376; DOI: 10.1021/jm00143a600 |
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.gamma.-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects Povl Krogsgaard-Larsen pp 1377 - 1383; DOI: 10.1021/jm00144a001 |
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Adenosine deaminase inhibitors. Conversion of a single chiral synthon into erythro- and threo-9-(2-hydroxy-3-nonyl)adenines Gerard Bastian, Michel Bessodes, Raymond P. Panzica, Elie Abushanab, Shih Fong Chen, Johanna D. Stoeckler, and Robert E. Parks pp 1383 - 1385; DOI: 10.1021/jm00144a002 |
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Inhibition of thymidylate synthetase by 5-alkynyl-2'-deoxyuridylates Philip J. Barr, Patricia A. Nolan, Daniel V. Santi, and Morris J. Robins pp 1385 - 1388; DOI: 10.1021/jm00144a003 |
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Cell-specific ligands for selective drug delivery to tissues and organs Mitree M. Ponpipom, Robert L. Bugianesi, James C. Robbins, T. W. Doebber, and T. Y. Shen pp 1388 - 1395; DOI: 10.1021/jm00144a004 |
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Influence of fluorine substitution on the site of enzymic O-methylation of fluorinated norepinephrines Cyrus R. Creveling, Elizabeth T. McNeal, Daniele Cantacuzene, and Kenneth L. Kirk pp 1395 - 1399; DOI: 10.1021/jm00144a005 |
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5-Fluoro- and 5-chlorocyclophosphamide: synthesis, metabolism, and antitumor activity of the cis and trans isomers Allan B. Foster, Michael Jarman, Ryszard W. Kinas, Johannes M. S. Van Maanen, Grahame N. Taylor, John L. Gaston, Ann Parkin, and Anthony C. Richardson pp 1399 - 1403; DOI: 10.1021/jm00144a006 |
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Synthesis of 3-hydroxycyclophosphamide and studies related to its possible role in the metabolism of cyclophosphamide Joan A. Brandt, Susan Marie Ludeman, Gerald Zon, William Egan, John A. Todhunter, and Ruth Dickerson pp 1404 - 1408; DOI: 10.1021/jm00144a007 |
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Biological activities of photoaffinity labeling analogs of kinins and their irreversible effects on kinin receptors Emanuel Escher, Endre Laczko, Gaetan Guillemette, and Domenico Regoli pp 1409 - 1413; DOI: 10.1021/jm00144a008 |
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Photoelectron spectra of psychotropic drugs. 6. Relationships between physical properties and pharmacological actions of amphetamine analogs L. N. Domelsmith, Thomas A. Eaton, K. N. Houk, G. M. Anderson, R. A. Glennon, A. T. Shulgin, N. Castagnoli, and P. A. Kollman pp 1414 - 1421; DOI: 10.1021/jm00144a009 |
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Comparison of the inhibition of methotrexate-sensitive and -resistant Lactobacillus casei cell cultures with purified Lactobacillus casei dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-substituted-phenyl)-s-triazines. Use of quantitative structure-activity relationships in making inferences about the mechanism of resistance and the structure of the enzyme in situ compared with the enzyme in vitro Eugene A. Coats, Clara S. Genther, Stephen W. Dietrich, Zong Ru Guo, and Corwin Hansch pp 1422 - 1429; DOI: 10.1021/jm00144a010 |
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Structure-activity relationships of the cycloalkyl ring of phencyclidine Roy L. McQuinn, Edward J. Cone, Harlan E. Shannon, and Tsung-Ping Su pp 1429 - 1432; DOI: 10.1021/jm00144a011 |
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.alpha.-Adrenergic agents. 1. Direct-acting .alpha.1 agonists related to methoxamine R. M. DeMarinis, W. M. Bryan, D. H. Shah, J. P. Hieble, and R. G. Pendleton pp 1432 - 1437; DOI: 10.1021/jm00144a012 |
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(-)-4-Hydroxymorphinanones: their synthesis and analgesic activity Awinash Manmade, Haldean C. Dalzell, John F. Howes, and Raj K. Razdan pp 1437 - 1440; DOI: 10.1021/jm00144a013 |
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Aporphines. 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines John L. Neumeyer, George W. Arana, Say Jong Law, Jeffrey S. Lamont, Nora S. Kula, and Ross J. Baldessarini pp 1440 - 1445; DOI: 10.1021/jm00144a014 |
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Analgesic narcotic antagonists. 8. 7.alpha.-Alkyl-4,5.alpha.-epoxymorphinan-6-ones Michael P. Kotick, David L. Leland, Joseph O. Polazzi, John F. Howes, and Ann R. Bousquet pp 1445 - 1450; DOI: 10.1021/jm00144a015 |
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Methotrexate analogs. 14. Synthesis of new .gamma.-substituted derivatives as dihydrofolate reductase inhibitors and potential anticancer agents Andre Rosowsky, Ronald Forsch, Jack Uren, and Michael Wick pp 1450 - 1455; DOI: 10.1021/jm00144a016 |
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Antihypertensive pyrrolo[1,2-c]quinazolines and pyrrolo[1,2-c]quinazolinones Victor T. Bandurco, Elizabeth Malloy Wong, Seymour D. Levine, and Zoltan G. Hajos pp 1455 - 1460; DOI: 10.1021/jm00144a017 |
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2-(Isoxazolylethenyl)phenoxypropanolamines: a new class of .beta.-receptor antagonists with antihypertensive activity Albrecht Franke, Fritz F. Frickel, Josef Gries, Dieter Lenke, Rainer Schlecker, and Peter D. Thieme pp 1460 - 1464; DOI: 10.1021/jm00144a018 |
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2,3-Dihydrobenzofuran-2-ones: a new class of highly potent antiinflammatory agents Annemarie Closse, Walter Haefliger, Daniel Hauser, Hans Ulrich Gubler, Beatrice Dewald, and Marco Baggiolini pp 1465 - 1471; DOI: 10.1021/jm00144a019 |
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Synthesis of some novel amodiaquine analogs as potential antimalarial and antifilarial compounds Meilin Go, Tonglan Ngiam, and Alfred S. C. Wan pp 1471 - 1475; DOI: 10.1021/jm00144a020 |
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3-Phenylpiperidines. Central dopamine-autoreceptor stimulating activity Uli Hacksell, Lars Erik Arvidsson, Uno Svensson, J. Lars G. Nilsson, Domingo Sanchez, Hakan Wikstroem, Per Lindberg, Stephan Hjorth, and Arvid Carlsson pp 1475 - 1482; DOI: 10.1021/jm00144a021 |
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Isomeric phenylthioimidazo[1,2-a]pyridines as anthelmintics Richard J. Bochis, Leonard E. Olen, M. H. Fisher, Robert A. Reamer, George Wilks, Joyce E. Taylor, and George Olson pp 1483 - 1487; DOI: 10.1021/jm00144a022 |
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Chemical modification of aminoglycosides. 3. Synthesis of 2"-deoxykanamycins from neamine R. J. Reid, S. A. Mizsak, L. M. Reineke, G. E. Zurenko, K. F. Stern, and B. J. Magerlein pp 1487 - 1492; DOI: 10.1021/jm00144a023 |
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Synthesis and in vitro antimicrobial property of o-carborane derivatives Tetsushi Totani, Katsutoshi Aono, Kiyoe Yamamoto, and Katsuya Tawara pp 1492 - 1499; DOI: 10.1021/jm00144a024 |
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Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake Thomas Hoegberg, Bengt Ulff, Anna L. Renyi, and Svante B. Ross pp 1499 - 1507; DOI: 10.1021/jm00144a025 |
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Synthesis and platelet aggregation inhibitory activity of 4,5-bis(aryl)-2-substituted-thiazoles Ronald H. Rynbrandt, Edward E. Nishizawa, Doris P. Balgoyen, A. Rene Mendoza, and Kathleen A. Annis pp 1507 - 1510; DOI: 10.1021/jm00144a026 |
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5'-Chloropuromycin. Inhibition of protein synthesis and antitrypanosomal activity Robert Vince, Heejoo Lee, A. S. Narang, and Frances N. Shirota pp 1511 - 1514; DOI: 10.1021/jm00144a027 |
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Synthesis of S-(3-deazaadenosyl)-L-homocysteine J. A. Montgomery, H. J. Thomas, M. C. Thorpe, and P. K. Chiang pp 1514 - 1516; DOI: 10.1021/jm00144a028 |
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Analgesic narcotic antagonists. 9. 6-Methylene-8.beta.-alkyl-N-(cycloalkylmethyl)-3-hydroxy- or -methoxymorphinans Joseph O. Polazzi, Michael P. Kotick, John F. Howes, and Ann R. Bousquet pp 1516 - 1518; DOI: 10.1021/jm00144a029 |
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Substituted imidazo[1,2-a]pyridine-2-carbamate anthelmintics Richard J. Bochis, Leonard E. Olen, Frank S. Waksmunski, Helmut Mrozik, Philip Eskola, Peter Kulsa, George Wilks, Joyce E. Taylor, John R. Egerton, and et al. pp 1518 - 1521; DOI: 10.1021/jm00144a030 |
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Chemistry and hypoglycemic activity of benzimidoylpyrazoles James R. Shroff, Victor Bandurco, Rohit Desai, Sidney Kobrin, and Peter Cervoni pp 1521 - 1525; DOI: 10.1021/jm00144a031 |
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Efficient synthesis of 14-hydroxymorphinans from codeine Martin A. Schwartz and Rebecca A. Wallace pp 1525 - 1528; DOI: 10.1021/jm00144a032 |
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Purine acyclic nucleosides. Nitrogen isosteres of 9-[(2-hydroxyethoxy)methyl] guanine as candidate antivirals James L. Kelley, Mark P. Krochmal, and Howard J. Schaeffer pp 1528 - 1531; DOI: 10.1021/jm00144a033 |
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Synthesis and .beta.-lactamase inhibitory properties of 2.beta.-(chloromethyl)-2.alpha.-methylpenam-3.alpha.-carboxylic acid 1,1-dioxide William J. Gottstein, Leonard B. Crast, Robert G. Graham, Ute J. Haynes, and Donald N. McGregor pp 1531 - 1534; DOI: 10.1021/jm00144a034 |
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Interaction of aromatic dyes with the coenzyme A binding site of choline acetyltransferase Henry G. Mautner, Robert E. Merrill, Stephen F. Currier, and Gregory Harvey pp 1534 - 1537; DOI: 10.1021/jm00144a035 |
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Interaction of 5-ethynyl-2'-deoxyuridylate with thymidylate synthetase Peter V. Danenberg, Ram S. Bhatt, Nitya G. Kundu, Kathleen Danenberg, and Charles Heidelberger pp 1537 - 1540; DOI: 10.1021/jm00144a036 |
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Book Reviews pp 1541 - 1546; DOI: 10.1021/jm00144a600 |
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Additions and Corrections - Estrogen Receptor Based Imaging Agents. 1. Synthesis and Receptor Binding Affinity of Some Aromatic and D-Ring Halogenated Estrogens. Daniel F. Heiman, Stephen G. Senderoff, John A. Katzenellenbogen, and Richard J. Neeley pp 1540 - 1540; DOI: 10.1021/jm00144a601 |
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Additions and Corrections - Some Short-Chain N6-Substituted Adenosine Analogues with Antitumor Properties. M. H .Fleysher, R. J. Bernacki, and G. A. Bullard pp 1540 - 1540; DOI: 10.1021/jm00144a602 |
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Additions and Corrections - In Vitro Activity of 2-Alkyl-3-hydroxy-1,4-naphthoquinones against Theileria parva Peter Boehm, Kelvin Cooper, Alan T. Hudson, Jane P. Elphick, and Nicholas McHardy pp 1540 - 1540; DOI: 10.1021/jm00144a603 |